Rene Mosier is a character played by Shannen Doherty in Mallrats. At the start of the film she is Brodie Bruce's girlfriend; she also dates Shannon Hamilton, his arch-nemesis. A confirmed shopper, she claims to have no respect for people without a shopping agenda.

In the film, she is first seen in a comically small twin bed next to Brodie. She knocks on his skull to wake him, and he immediately starts to play a video game he had suspended before going to sleep. As the scene unfolds, it becomes clear that Rene is fed up with Brodie's thoroughly uninspired antics and ensuing lack of sex drive, which prompts him to utter, "Hell hath no fury like a woman scorned for Sega." They argue, and she exits through his basement bedroom's window to avoid being seen by his overbearing mother. On her way out, she tosses a letter at Brodie indicating that their relationship is over.

Later in the film she has sex with him in a mall elevator.